Snail + Slug (pSer246) antibody (AbBy Fluor® 680)

Catalog No. ABIN6980709

This anti- antibody is a Rabbit Polyclonal antibody detecting in FACS. Suitable for Human.

Quick Overview for Snail + Slug (pSer246) antibody (AbBy Fluor® 680) (ABIN6980709)

Target: Snail + Slug

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: AbBy Fluor® 680

Application: Flow Cytometry (FACS)

Product Details

Binding Specificity: pSer246

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human SNAIL around the phosphorylation site of Ser246

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Snail + Slug

Background:

Synonyms: SNAIL + SLUG phospho S246 + S251, SNAIL + SLUG phospho Ser246 + Ser251, SNAILSer246 + SLUGSer251, dJ710H13.1, MGC10182, Neural crest transcription factor Slug, Protein sna, Protein snail homolog 1, Protein snail homolog 2, Protein snail homolog, Slug homolog zinc finger protein, Slug zinc finger protein, SLUGH, SLUGH 1, SLUGH1, SLUGH2, SNA, Sna protein, SNAH, SNAI 2, snai1, SNAI1_HUMAN, Snai2, SNAI2_HUMAN, Snail 2, Snail homolog 1 Drosophila, Snail homolog 2, Snail2, WS 2D, WS2D, Zinc finger protein SLUG, Zinc finger protein SNAI1, Zinc finger protein SNAI2.

Background: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin. SLUG is involved in epithelial-mesenchymal transitions (EMT) involving E-cadherin repression which is known to play an important role in tumor progression amd neural tube formation. SLUG also has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects (referenced from Entrez gene).

Gene ID: 6311

UniProt: O95863